2009 ICOSR - Int. Congress On Schizophrenia Research - 28Mar-1Apr'09 - San Diego

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2009 INTERNATIONAL CONGRESS ON SCHIZOPHRENIA RESEARCH
Saturday, 28 March - Wednesday, 01 April, 2009
Manchester Grand Hyatt, San Diego, California, USA
http://www.schizophreniacongress.org/

The INTERNATIONAL CONGRESS ON SCHIZOPHRENIA RESEARCH is a biennial meeting where scientists representing the broad range of disciplines involved with discovery in schizophrenia gather to exchange data, techniques, and ideas. Attendees are current contributors to the scientific literature and participate actively in poster sessions, oral presentations, and informal exchanges.

Program http://www.schizophreniacongress.org/programOfficial.php

Online Itinerary Planner to view specific presentations http://icosr.abstractcentral.com/itin.jsp. You can also search abstracts, titles, or authors.

Handwriting movement analysis results will be presented using international patent pending MovAlyzeR movement recording software by www.neuroscript.net:
Mon, Mar 30, 3:30 PM Elizabeth Ballroom F
Session Title: Side-effects of Antipsychotic Drugs: Epidemiology, Mechanisms of Action, Measurement, and Treatment
M. Caligiuri; H. L. Teulings; A. Niculescu; C. E. Dean; J. B. Lohr
Handwriting Movement Kinematics for Quantifying Antipsychotic-Induced EPS .

Presentations on human movement:

__Sun, Mar 29, 12:00 - 2:30 pm__Posters__Douglas Pavilion - L1__
99. Neural Correlates of Inhibitory Motor Control in Schizophrenia Patients and Their Biological Relatives.
M. K. Hall; J. W. Nelson; V. M. Goghari; A. W. MacDonald; J. J. Stanwyck; S. R. Sponheim
100. Genetic Aspects of Motor Inhibition in Patients with Schizophrenia and Their Non-Psychotic Relatives.
J. W. Nelson; M. K. Hall; V. M. Goghari; A. W. MacDonald; J. J. Stanwyck; S. R. Sponheim
128. Prediction in smooth pursuit of schizophrenic patients.
A. Sprenger; W. Heide; M. Nagel; R. Lencer

__Mon, Mar 30, 12:00 - 2:30 pm__Posters__Douglas Pavilion - L1__
33. A Unitary Model for the Motor Origin of Schizophrenia and Bipolar Disorder.
J. v. Hoof
34. Mind in Motion - Psychopathology in Patients with Schizophrenia is Reflected in Nonverbal Behavior Measured by Motion Energy Analysis (MEA).
Z. Kupper; F. Ramseyer; H. Hoffmann; W. Tschacher
187. Instrumental assessment of movement disorders in patients with schizophrenia, their healthy siblings and controls.
J. Koning; P. N. van Harten; R. S. Kahn
192. An innovating tool for the early diagnosis of schizophrenia and other psychiatric disorders.
H. Wilquin; Y. Delevoye-Turrell

__Mon, Mar 30, 3:30 PM__Oral presentation__Elizabeth Ballroom F__
Handwriting Movement Kinematics for Quantifying Antipsychotic-Induced EPS .
M. Caligiuri; H. L. Teulings; A. Niculescu; C. E. Dean; J. B. Lohr

__Wed, Apr 01, 4:45 PM__Oral Presentation__Elizabeth Ballroom F__
Impaired Motor Control in Adolescents at High Risk for Schizophrenia.
T. Manschreck; L. J. Seidman; S. V. Faraone; M. T. Tsuang; B. A. Maher

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PowerPoint presentation is attached for download.

ICOSR2009 Proceedings, Page 33.
Category: 3. Drug Side Effects & Physical Illness

Handwriting Movement Kinematics for Quantifying Antipsychotic-Induced EPS
M. Caligiuri1; H. L. Teulings2; A. Niculescu3, 4; C. E. Dean5; J. B. Lohr1
1. UCSD, La Jolla, CA, USA.
2. Neuroscript, LLC, Tempe, AZ, USA.
3. Indiana University, Indianapolis, IN, USA.
4. Indianapolis VA Medical Center, Indianapolis, IN, USA.
5. Minneapolis VA, Minneapolis, MN, USA.

Ongoing monitoring of antipsychotic-induced extrapyramidal side effects (EPS) is important to maximize treatment outcome and improve medication compliance. Conventional clinical assessments of EPS appear insensitive to differences across various atypical antipsychotics and examiner bias can reduce their reliability. Instrumental methods emerged as a remedy to these problems, however, these systems have had limited clinical utility because of their complexity and cost. We developed a novel method based on quantifying handwriting movements that overcomes previous limitations of complexity and cost. In our study we test the hypothesis that handwriting movement abnormalities are associated with severity of EPS but are independent of age, severity of psychosis, depression, or other factors that can bias the clinical assessment of EPS. We also tested whether handwriting movements differed across four commonly used atypical antipsychotics. Handwriting movements from 87 psychosis patients and 45 healthy comparison subjects were quantified during a loop-drawing task. Participants were instructed to draw continuous loops 2 cm high from left to right across a digitizing tablet. Samples were recorded and analyzed using commercial software. Kinematic variables included vertical loop size and peak velocity, relative time to peak velocity, and pen contact duration per stroke for both primary and secondary submovements. Patients with clinically determined EPS exhibited smaller vertical heights (p<0.001), lower peak velocities (p<0.05), longer times to peak velocity (p<0.05), and increased duration of pen contact (p<0.05) compared to patients without EPS. Patients treated with aripiprazole or risperidone exhibited significantly more impaired handwriting movements than patients treated with quetiapine or olanzapine, especially for peak velocity (p<0.01), whereas, clinical EPS assessments were insensitive to these medication differences. Unlike clinical EPS assessments, kinematic handwriting variables were independent of severity of positive and negative symptoms of psychosis, depression, or demographic variables. These findings support the high specificity of our kinematic handwriting measures to EPS. Differences between various antipsychotic medications suggest that handwriting kinematics may be useful in measuring the effects of switching medication in patients with pre-existing EPS.
Research Supported by NIH grant R44 MH073192.